Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II

Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II

The RAS isoforms (KRAS, HRAS and NRAS) have distinct cancer type-specific profiles. NRAS mutations are the second most prevalent RAS mutations in skin and hematological malignancies. Although RAS proteins were considered undruggable for decades, isoform and mutation-specific investigations have prod...

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Bibliographic Details
Main Authors: Teklab Gebregiworgis, Jonathan Yui-Lai Chan, Douglas A. Kuntz, Gilbert G. Privé, Christopher B. Marshall, Mitsuhiko Ikura
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:European Journal of Cell Biology
Subjects:
NRAS
Oncogenic mutation
RAS superfamily small GTPases
Crystal structure
Induced fit
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933524000311

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http://www.sciencedirect.com/science/article/pii/S0171933524000311

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