Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms

Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms

Abstract In chronic kidney disease (CKD), high serum phosphate concentration is associated with cardiovascular disease and deterioration in renal function. In early CKD, the serum phosphate concentration is normal due to increased fractional excretion of phosphate. Our premise was that high phosphat...

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Bibliographic Details
Main Authors: Rafael Santamaría, Juan M. Díaz-Tocados, M. Victoria Pendón-Ruiz de Mier, Ana Robles, M. Dolores Salmerón-Rodríguez, Erena Ruiz, Noemi Vergara, Escolástico Aguilera-Tejero, Ana Raya, Rosa Ortega, Arnold Felsenfeld, Juan R. Muñoz-Castañeda, Alejandro Martín-Malo, Pedro Aljama, Mariano Rodríguez
Format: Article
Language:English
Published: Nature Portfolio 2018-09-01
Series:Scientific Reports
Subjects:
Klotho Expression
High Phosphate Concentrations
Overt Proteinuria
Mangiferin
Excessive Phosphaturia
Online Access:https://doi.org/10.1038/s41598-018-32065-2

Internet

https://doi.org/10.1038/s41598-018-32065-2

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