Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs

Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs

Age-related somatic genomic alterations in hematopoietic cell lines have been well characterized in humans; however, this phenomenon has not been well studied in other species. Next-generation sequencing-based liquid biopsy testing for cancer detection was recently developed for dogs and has been us...

Full description

Bibliographic Details
Main Authors: Kristina M. Kruglyak, Allison L. O’Kell, Todd A. Cohen, Maggie A. Marshall, Carlos A. Ruiz-Perez, Francesco Marass, John A. Tynan, Susan C. Hicks, Katherine M. Lytle, Ashley Phelps-Dunn, Gina Brandstetter, Chelsea D. Warren, Lauren R. DiMarzio, Michelle C. Rosentel, Lilian K. Wong, Lisa M. McLennan, Jill M. Rafalko, Daniel S. Grosu, Jason Chibuk, Ilya Chorny, Angela L. McCleary-Wheeler, Andi Flory, Dana W. Y. Tsui
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Veterinary Sciences
Subjects:
clonal hematopoiesis of indeterminate potential (CHIP)
age-related clonal hematopoiesis (ARCH)
copy number variant (CNV)
next-generation sequencing (NGS)
somatic
germline
Online Access:https://www.mdpi.com/2306-7381/10/7/455

Internet

https://www.mdpi.com/2306-7381/10/7/455

Similar Items