Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice

Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice

Abstract Early life nutrition can reprogram development and exert long‐term consequences on body weight regulation. In mice, maternal high‐fat diet (HFD) during lactation predisposed male but not female offspring to diet‐induced obesity when adult. Molecular and cellular changes in the hypothalamus...

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Bibliographic Details
Main Authors: Yanchao Xu, Dengbao Yang, Lu Wang, Elżbieta Król, Mohsen Mazidi, Li Li, Yi Huang, Chaoqun Niu, Xue Liu, Sin Man Lam, Guanghou Shui, Alex Douglas, John R. Speakman
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Advanced Science
Subjects:
hypothalamic reprogramming
lactation
maternal high‐fat diet
neurogenesis
sex‐differential offspring obesity
Online Access:https://doi.org/10.1002/advs.202305472

Internet

https://doi.org/10.1002/advs.202305472

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