Iguratimod Attenuates Macrophage Polarization and Antibody-Mediated Rejection After Renal Transplant by Regulating KLF4

Iguratimod Attenuates Macrophage Polarization and Antibody-Mediated Rejection After Renal Transplant by Regulating KLF4

Background: This study aimed to explore the effect and mechanism of iguratimod (IGT) on M1 macrophage polarization and antibody-mediated rejection (ABMR) after renal transplant.Methods: Bioinformatics analysis was performed using three public databases derived from the GEO database. Sprague–Dawley (...

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Bibliographic Details
Main Authors: Zhou Hang, Jintao Wei, Ming Zheng, Zeping Gui, Hao Chen, Li Sun, Shuang Fei, Zhijian Han, Jun Tao, Zijie Wang, Ruoyun Tan, Min Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
macrophage polarization
antibody-mediated rejection
KLF4
iguratimod
kidney transplant
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.865363/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.865363/full

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