Dihydropyridine-derived calcium channel blocker as a promising anti-hantavirus entry inhibitor

Dihydropyridine-derived calcium channel blocker as a promising anti-hantavirus entry inhibitor

Hantaviruses, the causative agent for two types of hemorrhagic fevers, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), are distributed from Eurasia to America. HFRS and HPS have mortality rates of up to 15% or 45%, respectively. Currently, no certified therapeut...

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Bibliographic Details
Main Authors: Bin Wang, Jiawei Pei, Hui Zhang, Jia Li, Yamei Dang, He Liu, Yuan Wang, Liang Zhang, Libin Qi, Yuewu Yang, Linfeng Cheng, Yangchao Dong, Airong Qian, Zhikai Xu, Yingfeng Lei, Fanglin Zhang, Wei Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
Hantaan virus
hantavirus
bunyavirales
hemorrhagic fever with renal syndrome
hantavirus pulmonary syndrome
antivirals
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.940178/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.940178/full

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