Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease

Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease

Abstract The long-lived Chilean rodent (Octodon degus) has been reported to show spontaneous age-dependent neuropathology and cognitive impairments similar to those observed in human AD. However, the handful of published papers on degus of differing genetic backgrounds yield inconsistent findings ab...

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Bibliographic Details
Main Authors: Zhiqun Tan, B. Maximiliano Garduño, Pedro Fernández Aburto, Lujia Chen, Nicole Ha, Patricia Cogram, Todd C. Holmes, Xiangmin Xu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Acta Neuropathologica Communications
Subjects:
Degu
Natural model
Outbred
Behavioral
Immunostaining
Comprehensive investigation
Online Access:https://doi.org/10.1186/s40478-022-01481-x

Internet

https://doi.org/10.1186/s40478-022-01481-x

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