53BP1: Keeping It under Control, Even at a Distance from DNA Damage

53BP1: Keeping It under Control, Even at a Distance from DNA Damage

Double-strand breaks (DSBs) are toxic lesions that can be generated by exposure to genotoxic agents or during physiological processes, such as during V(D)J recombination. The repair of these DSBs is crucial to prevent genomic instability and to maintain cellular homeostasis. Two main pathways partic...

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Bibliographic Details
Main Authors: Emilie Rass, Simon Willaume, Pascale Bertrand
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Genes
Subjects:
53BP1
homologous recombination
non-homologous end joining
double-strand break repair
lamins
shieldin
Online Access:https://www.mdpi.com/2073-4425/13/12/2390

Internet

https://www.mdpi.com/2073-4425/13/12/2390

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