Signaling mechanisms of the platelet glycoprotein Ib-IX complex

Signaling mechanisms of the platelet glycoprotein Ib-IX complex

The glycoprotein Ib–IX (GPIb-IX) complex mediates initial platelet adhesion to von Willebrand factor (VWF) immobilized on subendothelial matrix and endothelial surfaces, and transmits VWF binding-induced signals to stimulate platelet activation. GPIb-IX also functions as part of a mechanosensor to c...

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Bibliographic Details
Main Authors: Yaping Zhang, Samuel M Ehrlich, Cheng Zhu, Xiaoping Du
Format: Article
Language:English
Published: Taylor & Francis Group 2022-08-01
Series:Platelets
Subjects:
glycoprotein ib (gpib)
integrin
intracellular signaling
platelet activation
thrombosis
von willebrand factor
Online Access:http://dx.doi.org/10.1080/09537104.2022.2071852

Internet

http://dx.doi.org/10.1080/09537104.2022.2071852

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