A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs
Herein, we report the design of a focused library of novel bacterial topoisomerase inhibitors (NBTIs) based on innovative mainly monocyclic right-hand side fragments active against DNA gyrase and Topo IV. They exhibit a very potent and wide range of antibacterial activity, even against some of the m...
| Huvudupphovsmän: | , , , , , , , , |
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| Materialtyp: | Artikel |
| Språk: | English |
| Publicerad: |
MDPI AG
2021-07-01
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| Serie: | Antibiotics |
| Ämnen: | |
| Länkar: | https://www.mdpi.com/2079-6382/10/7/862 |