The identification of effective tumor-suppressing neoantigens using a tumor-reactive TIL TCR-pMHC ternary complex

The identification of effective tumor-suppressing neoantigens using a tumor-reactive TIL TCR-pMHC ternary complex

Abstract Neoantigens are ideal targets for cancer immunotherapy because they are expressed de novo in tumor tissue but not in healthy tissue and are therefore recognized as foreign by the immune system. Advances in next-generation sequencing and bioinformatics technologies have enabled the quick ide...

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Bibliographic Details
Main Authors: Sang Hoon Kim, Bo Ryeong Lee, Sung-Min Kim, Sungsik Kim, Min-seok Kim, Jaehyun Kim, Inkyu Lee, Hee-Soo Kim, Gi-Hoon Nam, In-San Kim, Kyuyoung Song, Yoonjoo Choi, Dong-Sup Lee, Woong-Yang Park
Format: Article
Language:English
Published: Nature Publishing Group 2024-06-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01259-2

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https://doi.org/10.1038/s12276-024-01259-2

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