Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [18F]PSS232 PET/MRI study

Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [18F]PSS232 PET/MRI study

Abstract Background Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the initial pathophysiological mechanism of Alzheimer’s disease (AD). The study ai...

Full description

Bibliographic Details
Main Authors: Jie Wang, Yingfang He, Xing Chen, Lin Huang, Junpeng Li, Zhiwen You, Qi Huang, Shuhua Ren, Kun He, Roger Schibli, Linjing Mu, Yihui Guan, Qihao Guo, Jun Zhao, Fang Xie
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Metabotropic glutamate receptor 5
Amyloid deposition
Glucose metabolism
Cognitive performance
Plasma biomarkers
Online Access:https://doi.org/10.1186/s13195-024-01385-z

Internet

https://doi.org/10.1186/s13195-024-01385-z

Similar Items