HIF1 and ID1 Interplay Confers Adaptive Survival to HIF1α-Inhibition

HIF1 and ID1 Interplay Confers Adaptive Survival to HIF1α-Inhibition

Hypoxia is a universal pathological feature of solid tumors. Hypoxic tumor cells acquire metastatic and lethal phenotypes primarily through the activities of hypoxia-inducible factor 1 alpha (HIF1α). Therefore, HIF1α is considered as a promising therapeutic target. However, HIF inhibitors have not p...

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Bibliographic Details
Main Authors: Hao Geng, Hyun-Kyung Ko, Janet Pittsenbarger, Christopher T. Harvey, Changhui Xue, Qiong Liu, Sadie Wiens, Sushant K. Kachhap, Tomasz M. Beer, David Z. Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ID1
hypoxia
resistance
HIF1
targeted-treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.724059/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.724059/full

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