Oxyresveratrol Inhibits TNF-α-Stimulated Cell Proliferation in Human Immortalized Keratinocytes (HaCaT) by Suppressing AKT Activation

Oxyresveratrol Inhibits TNF-α-Stimulated Cell Proliferation in Human Immortalized Keratinocytes (HaCaT) by Suppressing AKT Activation

Psoriasis is a complex inflammatory disease characterized by hyperproliferative keratinocyte caused by active PI3K/AKT signaling. TNF-α concentrated in the psoriatic lesions stimulates AKT activation. We previously discovered that oxyresveratrol inhibited inflammation via suppressing AKT phosphoryla...

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Bibliographic Details
Main Authors: Nitwara Wikan, Phateep Hankittichai, Phatarawat Thaklaewphan, Saranyapin Potikanond, Wutigri Nimlamool
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
psoriasis
PI3K
AKT
keratinocyte
HaCaT cells
proliferation
Online Access:https://www.mdpi.com/1999-4923/14/1/63

Internet

https://www.mdpi.com/1999-4923/14/1/63

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