GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes

GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes

We previously reported that mice lacking the protein optic atrophy 1 (OPA1 BKO) in brown adipose tissue (BAT) display induction of the activating transcription factor 4 (ATF4), which promotes fibroblast growth factor 21 (FGF21) secretion as a batokine. FGF21 increases metabolic rates under baseline...

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Bibliographic Details
Main Authors: Jayashree Jena, Luis Miguel García-Peña, Eric T Weatherford, Alex Marti, Sarah H Bjorkman, Kevin Kato, Jivan Koneru, Jason H Chen, Randy J Seeley, E Dale Abel, Renata O Pereira
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-10-01
Series:eLife
Subjects:
brown adipose tissue
mitochondrial stress
integrated stress response
PERK
GDF15
Online Access:https://elifesciences.org/articles/86452

Internet

https://elifesciences.org/articles/86452

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