Transcriptional Profiling Reveals Mesenchymal Subtypes of Small Cell Lung Cancer with Activation of the Epithelial-to-Mesenchymal Transition and Worse Clinical Outcomes

Transcriptional Profiling Reveals Mesenchymal Subtypes of Small Cell Lung Cancer with Activation of the Epithelial-to-Mesenchymal Transition and Worse Clinical Outcomes

While molecular subtypes of small cell lung cancers (SCLC) based on neuroendocrine (NE) and non-NE transcriptional regulators have been established, the association between these molecular subtypes and recently recognized SCLC-inflamed (SCLC-I) tumors is less understood. In this study, we used gene...

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Bibliographic Details
Main Authors: Hae Jin Cho, Soon Auck Hong, Daeun Ryu, Sook-Hee Hong, Tae-Min Kim
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
small cell lung cancers
molecular taxonomy
mesenchymal tumors
epithelial-mesenchymal transformation
developmental trajectories
Online Access:https://www.mdpi.com/2072-6694/14/22/5600

Internet

https://www.mdpi.com/2072-6694/14/22/5600

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