Amyloid β Protein Aggravates Neuronal Senescence and Cognitive Deficits in 5XFAD Mouse Model of Alzheimer's Disease

Amyloid β Protein Aggravates Neuronal Senescence and Cognitive Deficits in 5XFAD Mouse Model of Alzheimer's Disease

Background: Amyloid β (Aβ) has been established as a key factor for the pathological changes in the brains of patients with Alzheimer's disease (AD), and cellular senescence is closely associated with aging and cognitive impairment. However, it remains blurred whether, in the AD brains, Aβ acce...

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Bibliographic Details
Main Authors: Zhen Wei, Xiao-Chun Chen, Yue Song, Xiao-Dong Pan, Xiao-Man Dai, Jing Zhang, Xiao-Li Cui, Xi-Lin Wu, Yuan-Gui Zhu
Format: Article
Language:English
Published: Wolters Kluwer 2016-01-01
Series:Chinese Medical Journal
Subjects:
Alzheimer's Disease; Amyloid β; Cognition; P16; Senescence
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=15;spage=1835;epage=1844;aulast=Wei

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http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=15;spage=1835;epage=1844;aulast=Wei

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