Amyloid β Protein Aggravates Neuronal Senescence and Cognitive Deficits in 5XFAD Mouse Model of Alzheimer's Disease

Amyloid β Protein Aggravates Neuronal Senescence and Cognitive Deficits in 5XFAD Mouse Model of Alzheimer's Disease

Background: Amyloid β (Aβ) has been established as a key factor for the pathological changes in the brains of patients with Alzheimer's disease (AD), and cellular senescence is closely associated with aging and cognitive impairment. However, it remains blurred whether, in the AD brains, Aβ acce...

Full description

Bibliographic Details
Main Authors:	Zhen Wei, Xiao-Chun Chen, Yue Song, Xiao-Dong Pan, Xiao-Man Dai, Jing Zhang, Xiao-Li Cui, Xi-Lin Wu, Yuan-Gui Zhu
Format:	Article
Language:	English
Published:	Wolters Kluwer 2016-01-01
Series:	Chinese Medical Journal
Subjects:	Alzheimer's Disease; Amyloid β; Cognition; P16; Senescence
Online Access:	http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=15;spage=1835;epage=1844;aulast=Wei

Similar Items

Midazolam alleviates cellular senescence in SH‐SY5Y neuronal cells in Alzheimer's disease
by: Ping Wang, et al.
Published: (2023-01-01)

The novel estrogen receptor modulator STX attenuates Amyloid-β neurotoxicity in the 5XFAD mouse model of Alzheimer's disease
by: Joseph F. Quinn, et al.
Published: (2022-11-01)

Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer’s Disease
by: Leela Paladugu, et al.
Published: (2021-01-01)

The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer’s Disease
by: Anna E. Bugrova, et al.
Published: (2021-12-01)

High-Throughput Sequencing to Investigate lncRNA-circRNA-miRNA-mRNA Networks Underlying the Effects of Beta-Amyloid Peptide and Senescence on Astrocytes
by: Yuxin Deng, et al.
Published: (2022-05-01)

Sex Differences between Neuronal Loss and the Early Onset of Amyloid Deposits and Behavioral Consequences in 5xFAD Transgenic Mouse as a Model for Alzheimer’s Disease
by: Chi Him Poon, et al.
Published: (2023-03-01)

Autosomal Dominant Alzheimer’s Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice
by: Carmen Romero-Molina, et al.
Published: (2024-02-01)

Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis
by: Chaska C. Walton, et al.
Published: (2020-05-01)

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
by: Ka Chun Tsui, et al.
Published: (2022-07-01)

RETRACTED ARTICLE: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease
by: Panchanan Maiti, et al.
Published: (2018-02-01)

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
by: Justyna Sosna, et al.
Published: (2018-03-01)

Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer’s Disease
by: Nathanael Matei, et al.
Published: (2022-08-01)

BETA-AMYLOID AS PATHOGENESIS OF ALZHEIMER DISEASE
by: Kadek Ary Mahendri Pattni
Published: (2013-07-01)

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model
by: Ryoichi Kimura, et al.
Published: (2009-02-01)

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain
by: Evgenia Salta, et al.
Published: (2016-09-01)

The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model
by: Kelly H. Forest, et al.
Published: (2021-04-01)

Ficus erecta Thunb. Leaves Ameliorate Cognitive Deficit and Neuronal Damage in a Mouse Model of Amyloid-β-Induced Alzheimer’s Disease
by: Eunjin Sohn, et al.
Published: (2021-04-01)

Clemastine Ameliorates Myelin Deficits via Preventing Senescence of Oligodendrocytes Precursor Cells in Alzheimer’s Disease Model Mouse
by: Yuan-Yuan Xie, et al.
Published: (2021-10-01)

The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling
by: Carolina Osorio, et al.
Published: (2019-06-01)

Tempeh attenuates cognitive deficit, antioxidant imbalance, and amyloid β of senescence-accelerated mice by modulating Nrf2 expression via MAPK pathway
by: Yin-Ching Chan, et al.
Published: (2018-11-01)

Indirubin-3'-monoxime rescues spatial memory deficits and attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer's disease
by: Yun Ding, et al.
Published: (2010-08-01)

Transferrin-Conjugated Melittin-Loaded L-Arginine-Coated Iron Oxide Nanoparticles for Mitigating Beta-Amyloid Pathology of the 5XFAD Mouse Brain
by: Moonseok Choi, et al.
Published: (2023-10-01)

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
by: Angelika Sabine Bader, et al.
Published: (2023-04-01)

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition
by: Brittani R. Price, et al.
Published: (2020-08-01)

Ethanol Alleviates Amyloid-β-Induced Toxicity in an Alzheimer’s Disease Model of Caenorhabiditis elegans
by: Shuju Bai, et al.
Published: (2021-11-01)

White Button Mushroom (<i>Agaricus bisporus)</i> Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer’s Disease
by: Thalia T. Dimopoulos, et al.
Published: (2022-10-01)

Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology
by: Nuria Suelves, et al.
Published: (2023-05-01)

Therapeutic Effects of Aβ-Specific Regulatory T Cells in Alzheimer’s Disease: A Study in 5xFAD Mice
by: Seon-Young Park, et al.
Published: (2024-01-01)

Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation
by: Geng Lin, et al.
Published: (2020-11-01)

Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease
by: Divna Lazic, et al.
Published: (2020-03-01)

Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
by: Karthivashan Govindarajan, et al.
Published: (2023-07-01)

The association of circulating amylin with β‐amyloid in familial Alzheimer's disease
by: Han Ly, et al.
Published: (2021-01-01)

Astrocyte Senescence and Alzheimer’s Disease: A Review
by: Xiaojuan Han, et al.
Published: (2020-06-01)

Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease
by: Richard E. Hartman, et al.
Published: (2006-12-01)

FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer’s Disease
by: Bisan Saleh, et al.
Published: (2022-08-01)

Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance
by: Weixi Feng, et al.
Published: (2020-10-01)

Cellular Senescence and Iron Dyshomeostasis in Alzheimer’s Disease
by: Shashank Masaldan, et al.
Published: (2019-06-01)

Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease: two triggers, one disease
by: Sofia Ferreira, et al.
Published: (2021-01-01)

Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models
by: Hee Yang Lee, et al.
Published: (2022-11-01)

Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia
by: Dietmar Rudolf Thal, et al.
Published: (2019-11-01)