Characterization of a novel T cell-engaging bispecific antibody for elimination of L1CAM-positive tumors

Characterization of a novel T cell-engaging bispecific antibody for elimination of L1CAM-positive tumors

Neural cell adhesion molecule L1 (L1CAM) is a cell-surface glycoprotein involved in cancer occurrence and migration. Up to today, L1CAM-targeted therapy appeared limited efficacy in clinical trials although quite a few attempts by monoclonal antibody (mAb) or chimeric antigen receptor T-cell therapy...

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Bibliographic Details
Main Authors: Yuan Yuan, Junyan Li, Jie Chen, Lei Han, Lei Wang, Yali Yue, Junjun Liu, Baohong Zhang, Yunsheng Yuan, Mingyuan Wu, Yanlin Bian, Yueqing Xie, Jianwei Zhu
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Neural cell adhesion molecule L1 (L1CAM)
T cell-engaging bispecific antibody
Immunotherapy
Anti-PD-1 antibody
Combination therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224004499

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http://www.sciencedirect.com/science/article/pii/S0753332224004499

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