Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa

Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa

Using cervical explant models and cervical tissue from ART-suppressed HIV+ women, the authors here show that resident memory T cells (TRM) in the cervical mucosa are preferentially infected and harbor more viral DNA, RNA and protein than non-TRM, suggesting that TRM may serve as viral reservoir in t...

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Bibliographic Details
Main Authors: Jon Cantero-Pérez, Judith Grau-Expósito, Carla Serra-Peinado, Daniela A. Rosero, Laura Luque-Ballesteros, Antonio Astorga-Gamaza, Josep Castellví, Tamara Sanhueza, Gustavo Tapia, Belen Lloveras, Marco A. Fernández, Julia G. Prado, Josep M. Solé-Sedeno, Antoni Tarrats, Carla Lecumberri, Laura Mañalich-Barrachina, Cristina Centeno-Mediavilla, Vicenç Falcó, Maria J. Buzon, Meritxell Genescà
Format: Article
Language:English
Published: Nature Portfolio 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12732-2

Internet

https://doi.org/10.1038/s41467-019-12732-2

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