Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa
Using cervical explant models and cervical tissue from ART-suppressed HIV+ women, the authors here show that resident memory T cells (TRM) in the cervical mucosa are preferentially infected and harbor more viral DNA, RNA and protein than non-TRM, suggesting that TRM may serve as viral reservoir in t...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12732-2 |
| _version_ | 1818841976395530240 |
|---|---|
| author | Jon Cantero-Pérez Judith Grau-Expósito Carla Serra-Peinado Daniela A. Rosero Laura Luque-Ballesteros Antonio Astorga-Gamaza Josep Castellví Tamara Sanhueza Gustavo Tapia Belen Lloveras Marco A. Fernández Julia G. Prado Josep M. Solé-Sedeno Antoni Tarrats Carla Lecumberri Laura Mañalich-Barrachina Cristina Centeno-Mediavilla Vicenç Falcó Maria J. Buzon Meritxell Genescà |
| author_facet | Jon Cantero-Pérez Judith Grau-Expósito Carla Serra-Peinado Daniela A. Rosero Laura Luque-Ballesteros Antonio Astorga-Gamaza Josep Castellví Tamara Sanhueza Gustavo Tapia Belen Lloveras Marco A. Fernández Julia G. Prado Josep M. Solé-Sedeno Antoni Tarrats Carla Lecumberri Laura Mañalich-Barrachina Cristina Centeno-Mediavilla Vicenç Falcó Maria J. Buzon Meritxell Genescà |
| author_sort | Jon Cantero-Pérez |
| collection | DOAJ |
| description | Using cervical explant models and cervical tissue from ART-suppressed HIV+ women, the authors here show that resident memory T cells (TRM) in the cervical mucosa are preferentially infected and harbor more viral DNA, RNA and protein than non-TRM, suggesting that TRM may serve as viral reservoir in the cervical mucosa. |
| first_indexed | 2024-12-19T04:34:38Z |
| format | Article |
| id | doaj.art-3aa422cb216c4cfc82538033c88d2d8f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:34:38Z |
| publishDate | 2019-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3aa422cb216c4cfc82538033c88d2d8f2022-12-21T20:35:48ZengNature PortfolioNature Communications2041-17232019-10-0110111610.1038/s41467-019-12732-2Resident memory T cells are a cellular reservoir for HIV in the cervical mucosaJon Cantero-Pérez0Judith Grau-Expósito1Carla Serra-Peinado2Daniela A. Rosero3Laura Luque-Ballesteros4Antonio Astorga-Gamaza5Josep Castellví6Tamara Sanhueza7Gustavo Tapia8Belen Lloveras9Marco A. Fernández10Julia G. Prado11Josep M. Solé-Sedeno12Antoni Tarrats13Carla Lecumberri14Laura Mañalich-Barrachina15Cristina Centeno-Mediavilla16Vicenç Falcó17Maria J. Buzon18Meritxell Genescà19Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de BarcelonaInfectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de BarcelonaInfectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de BarcelonaInfectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de BarcelonaInfectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de BarcelonaInfectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de BarcelonaPathology Department, Hospital Universitari Vall d’Hebron, UABPathology Department, Hospital Universitari Germans Trias i Pujol, BadalonaPathology Department, Hospital Universitari Germans Trias i Pujol, BadalonaPathology Department, Hospital del Mar, Parc de Salut Mar, Universitat Autònoma de BarcelonaFlow Cytometry Facility, Institut d’Investigació en Ciències de la Salut Germans Trias i PujolAIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de BarcelonaObstetrics and Gynecology Department, Hospital del Mar, Parc de Salut Mar, Universitat Autònoma de BarcelonaDepartment of Obstetrics and Gynecology, Hospital Universitari Germans Trias i Pujol, BadalonaDepartment of Obstetrics and Gynecology, Hospital Universitari Germans Trias i Pujol, BadalonaDepartment of Obstetrics and Gynecology, Hospital Universitari Vall d’Hebron, Universitat Autònoma de BarcelonaDepartment of Obstetrics and Gynecology, Hospital Universitari Vall d’Hebron, Universitat Autònoma de BarcelonaInfectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de BarcelonaInfectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de BarcelonaInfectious Diseases Department, Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), Universitat Autònoma de BarcelonaUsing cervical explant models and cervical tissue from ART-suppressed HIV+ women, the authors here show that resident memory T cells (TRM) in the cervical mucosa are preferentially infected and harbor more viral DNA, RNA and protein than non-TRM, suggesting that TRM may serve as viral reservoir in the cervical mucosa.https://doi.org/10.1038/s41467-019-12732-2 |
| spellingShingle | Jon Cantero-Pérez Judith Grau-Expósito Carla Serra-Peinado Daniela A. Rosero Laura Luque-Ballesteros Antonio Astorga-Gamaza Josep Castellví Tamara Sanhueza Gustavo Tapia Belen Lloveras Marco A. Fernández Julia G. Prado Josep M. Solé-Sedeno Antoni Tarrats Carla Lecumberri Laura Mañalich-Barrachina Cristina Centeno-Mediavilla Vicenç Falcó Maria J. Buzon Meritxell Genescà Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa Nature Communications |
| title | Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa |
| title_full | Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa |
| title_fullStr | Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa |
| title_full_unstemmed | Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa |
| title_short | Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa |
| title_sort | resident memory t cells are a cellular reservoir for hiv in the cervical mucosa |
| url | https://doi.org/10.1038/s41467-019-12732-2 |
| work_keys_str_mv | AT joncanteroperez residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT judithgrauexposito residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT carlaserrapeinado residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT danielaarosero residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT lauraluqueballesteros residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT antonioastorgagamaza residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT josepcastellvi residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT tamarasanhueza residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT gustavotapia residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT belenlloveras residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT marcoafernandez residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT juliagprado residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT josepmsolesedeno residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT antonitarrats residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT carlalecumberri residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT lauramanalichbarrachina residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT cristinacentenomediavilla residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT vicencfalco residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT mariajbuzon residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa AT meritxellgenesca residentmemorytcellsareacellularreservoirforhivinthecervicalmucosa |