Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells

Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells

Non-small cell lung cancer (NSCLC) is often characterized by an underlying mutation in the epidermal growth factor receptor (EGFR), contributing to aggressive metastatic disease. Methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate (CDODA-Me), a glycyrrhetinic acid derivative, reportedly improve...

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Bibliographic Details
Main Authors: Ebony Nottingham, Elizabeth Mazzio, Sunil Kumar Surapaneni, Shallu Kutlehria, Arindam Mondal, Ramesh Badisa, Stephen Safe, Arun K. Rishi, Mandip Singh
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Transcriptomic analysis
Combination therapy
Drug resistance
Erlotinib
Epidermal growth factor receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177921000629

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http://www.sciencedirect.com/science/article/pii/S2095177921000629

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