Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance

Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance

Objective: The fatty acid receptor 1 (FFAR1/GPR40) mediates fatty acid-dependent augmentation of glucose-induced insulin secretion (GIIS) in pancreatic β-cells. Genetically engineered Ffar1-knockout/congenic mice univocally displayed impaired fatty acid-mediated insulin secretion, but in vivo experi...

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Bibliographic Details
Main Authors: Sibylle Sabrautzki, Gabriele Kaiser, Gerhard K.H. Przemeck, Felicia Gerst, Estela Lorza-Gil, Madhura Panse, Tina Sartorius, Miriam Hoene, Susan Marschall, Hans-Ulrich Häring, Martin Hrabě de Angelis, Susanne Ullrich
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Molecular Metabolism
Subjects:
FFAR1/GPR40
Free fatty acids
Insulin secretion
ENU-mutated Ffar1
FFAR1 deficient mice
High fat diet
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877816302836

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http://www.sciencedirect.com/science/article/pii/S2212877816302836

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