TNF-α induces endothelial–mesenchymal transition promoting stromal development of pancreatic adenocarcinoma

TNF-α induces endothelial–mesenchymal transition promoting stromal development of pancreatic adenocarcinoma

Abstract Endothelial–mesenchymal transition (EndMT) is an important source of cancer-associated fibroblasts (CAFs), which facilitates tumour progression. PDAC is characterised by abundant CAFs and tumour necrosis factor-α (TNF-α). Here, we show that TNF-α strongly induces human endothelial cells to...

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Bibliographic Details
Main Authors: Marjorie Adjuto-Saccone, Philippe Soubeyran, Julie Garcia, Stéphane Audebert, Luc Camoin, Marion Rubis, Julie Roques, Bernard Binétruy, Juan Lucio Iovanna, Roselyne Tournaire
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03920-4

Internet

https://doi.org/10.1038/s41419-021-03920-4

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