Mechanism of Action of Botulinum Toxin A in Treatment of Functional Urological Disorders

Intravesical botulinum toxin (BoNT) injection is effective in reducing urgency and urinary incontinence. It temporarily inhibits the detrusor muscle contraction by blocking the release of acetylcholine (Ach) from the preganglionic and postganglionic nerves in the efferent nerves. BoNT-A also blocks...

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Bibliographic Details
Main Authors: Yu-Hua Lin, Bing-Juin Chiang, Chun-Hou Liao
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/12/2/129