Integration of In Silico Strategies for Drug Repositioning towards P38α Mitogen-Activated Protein Kinase (MAPK) at the Allosteric Site

Integration of In Silico Strategies for Drug Repositioning towards P38α Mitogen-Activated Protein Kinase (MAPK) at the Allosteric Site

P38α mitogen-activated protein kinase (p38α MAPK), one of the p38 MAPK isoforms participating in a signaling cascade, has been identified for its pivotal role in the regulation of physiological processes such as cell proliferation, differentiation, survival, and death. Herein, by shedding light on d...

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Bibliographic Details
Main Authors: Utid Suriya, Panupong Mahalapbutr, Thanyada Rungrotmongkol
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
drug repositioning
p38α MAPK
molecular docking
MD simulation
allosteric inhibitors
in silico screening
Online Access:https://www.mdpi.com/1999-4923/14/7/1461

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https://www.mdpi.com/1999-4923/14/7/1461

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