Cholesterol confers ferroptosis resistance onto myeloid-biased hematopoietic stem cells and prevents irradiation-induced myelosuppression

Cholesterol confers ferroptosis resistance onto myeloid-biased hematopoietic stem cells and prevents irradiation-induced myelosuppression

There is growing appreciation that hematopoietic alterations underpin the ubiquitous detrimental effects of metabolic disorders. The susceptibility of bone marrow (BM) hematopoiesis to perturbations of cholesterol metabolism is well documented, while the underlying cellular and molecular mechanisms...

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Bibliographic Details
Main Authors: Chaonan Liu, Weinian Liao, Jun Chen, Kuan Yu, Yiding Wu, Shuzhen Zhang, Mo Chen, Fang Chen, Song Wang, Tianmin Cheng, Junping Wang, Changhong Du
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
Hematopoietic stem cell
Cholesterol
Ferroptosis
Myeloid bias
Ionizing radiation
Myelosuppression
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000629

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http://www.sciencedirect.com/science/article/pii/S2213231723000629

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