USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells

USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells

In this study, we discovered that two human oral squamous carcinoma cell (OSCC) lines, SCC9 and SCC25, exhibited varied levels of permissivity to oncolytic HSV-1 T1012G replication and the differential virus yields may associate with the constitutive accumulation of two deubiquitinating enzymes USP1...

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Bibliographic Details
Main Authors: Ruitao Lu, Guangxian Wu, Meiling Chen, Dongmei Ji, Yonghong Liu, Grace Guoying Zhou, Wenmin Fu
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic HSV-1
deubiquitinating enzymes
USP18 and USP20
STING
viral replication
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001534

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http://www.sciencedirect.com/science/article/pii/S2372770521001534

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