Chronic Stress Alters Hippocampal Renin-Angiotensin-Aldosterone System Component Expression in an Aged Rat Model of Wolfram Syndrome

Chronic Stress Alters Hippocampal Renin-Angiotensin-Aldosterone System Component Expression in an Aged Rat Model of Wolfram Syndrome

Biallelic mutations in the gene encoding WFS1 underlie the development of Wolfram syndrome (WS), a rare neurodegenerative disorder with no available cure. We have previously shown that <i>Wfs1</i> deficiency can impair the functioning of the renin-angiotensin-aldosterone system (RAAS). T...

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Bibliographic Details
Main Authors: Marite Punapart, Riin Reimets, Kadri Seppa, Silvia Kirillov, Nayana Gaur, Kattri-Liis Eskla, Toomas Jagomäe, Eero Vasar, Mario Plaas
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Genes
Subjects:
Wolfram syndrome
<i>Wfs1</i> knock-out
GLP1-R agonist
liraglutide
7,8-DHF
RAAS
Online Access:https://www.mdpi.com/2073-4425/14/4/827

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https://www.mdpi.com/2073-4425/14/4/827

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