Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae.

The de novo biosynthetic machinery for both sphingolipid and ergosterol production in yeast is localized in the endoplasmic reticulum (ER) and Golgi. The interconnections between the two pathways are still poorly understood, but they may be connected in specialized membrane domains, and specific kno...

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Bibliographic Details
Main Authors: Fernando Alvarez-Vasquez, Howard Riezman, Yusuf A Hannun, Eberhard O Voit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3237449?pdf=render