Lipophosphoglycan From Dermotropic New World Leishmania Upregulates Interleukin-32 and Proinflammatory Cytokines Through TLR4 and NOD2 Receptors

Lipophosphoglycan From Dermotropic New World Leishmania Upregulates Interleukin-32 and Proinflammatory Cytokines Through TLR4 and NOD2 Receptors

Interleukin-32 (IL-32) is produced during Leishmania infection, but the components of the parasite that induce its production are unknown. An important multivirulence factor of Leishmania spp. protozoa is the lipophosphoglycan (LPG), which plays a crucial role in the host-parasite interaction. Here,...

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Bibliographic Details
Main Authors: Murilo Barros Silveira, Rodrigo Saar Gomes, Marina Tiemi Shio, Jeronimo Nunes Rugani, Larissa Ferreira Paranaiba, Rodrigo Pedro Soares, Fátima Ribeiro-Dias
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
IL-32
lipophosphoglycan
Leishmania braziliensis
Leishmania amazonensis
TLR4
NOD2
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.805720/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.805720/full

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