Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis in the Human Hepatoma Cell Line HepaRG

Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis in the Human Hepatoma Cell Line HepaRG

1,2-unsaturated pyrrolizidine alkaloids (PAs) belong to a group of secondary plant metabolites. Exposure to PA-contaminated feed and food may cause severe hepatotoxicity. A pathway possibly involved in PA toxicity is the disturbance of bile acid homeostasis. Therefore, in this study, the influence o...

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Bibliographic Details
Main Authors: Julia Waizenegger, Josephin Glück, Marcus Henricsson, Claudia Luckert, Albert Braeuning, Stefanie Hessel-Pras
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Foods
Subjects:
pyrrolizidine alkaloids
hepatotoxicity
HepaRG
cholestasis
bile acid
Online Access:https://www.mdpi.com/2304-8158/10/1/161

Internet

https://www.mdpi.com/2304-8158/10/1/161

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