The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality

The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality

Approximately 15% of cancers exhibit loss of the chromosomal locus 9p21.3 – the genomic location of the tumour suppressor gene CDKN2A and the methionine salvage gene methylthioadenosine phosphorylase (MTAP). A loss of MTAP increases the pool of its substrate methylthioadenosine (MTA), which binds to...

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Bibliographic Details
Main Authors: Chandler Bray, Cristina Balcells, Iain A. McNeish, Hector C. Keun
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Oncology
Subjects:
MTAP
MAT2A
PRMT5
methionine
metabolism
synthetic lethality
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1264785/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1264785/full

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