Regulation of the Membrane Trafficking of the Mechanosensitive Ion Channels TRPV1 and TRPV4 by Zonular Tension, Osmotic Stress and Activators in the Mouse Lens

Regulation of the Membrane Trafficking of the Mechanosensitive Ion Channels TRPV1 and TRPV4 by Zonular Tension, Osmotic Stress and Activators in the Mouse Lens

Lens water transport generates a hydrostatic pressure gradient that is regulated by a dual-feedback system that utilizes the mechanosensitive transient receptor potential vanilloid (TRPV) channels, TRPV1 and TRPV4, to sense changes in mechanical tension and extracellular osmolarity. Here, we investi...

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Bibliographic Details
Main Authors: Yosuke Nakazawa, Rosica S. Petrova, Yuki Sugiyama, Noriaki Nagai, Hiroomi Tamura, Paul J. Donaldson
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
lens
zonular tension
osmotic stress
cell volume
mechanosensors
TRPV1/4
Online Access:https://www.mdpi.com/1422-0067/22/23/12658

Internet

https://www.mdpi.com/1422-0067/22/23/12658

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