GRP75 Modulates Endoplasmic Reticulum–Mitochondria Coupling and Accelerates Ca<sup>2+</sup>-Dependent Endothelial Cell Apoptosis in Diabetic Retinopathy

GRP75 Modulates Endoplasmic Reticulum–Mitochondria Coupling and Accelerates Ca<sup>2+</sup>-Dependent Endothelial Cell Apoptosis in Diabetic Retinopathy

Endoplasmic reticulum (ER) and mitochondrial dysfunction play fundamental roles in the pathogenesis of diabetic retinopathy (DR). However, the interrelationship between the ER and mitochondria are poorly understood in DR. Here, we established high glucose (HG) or advanced glycosylation end products...

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Bibliographic Details
Main Authors: Yan Li, Hong-Ying Li, Jun Shao, Lingpeng Zhu, Tian-Hua Xie, Jiping Cai, Wenjuan Wang, Meng-Xia Cai, Zi-Li Wang, Yong Yao, Ting-Ting Wei
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomolecules
Subjects:
diabetic retinopathy
ER–mitochondria coupling
IP3R1–GRP75–VDAC1 axis
mitochondrial Ca<sup>2+</sup>
apoptosis
Online Access:https://www.mdpi.com/2218-273X/12/12/1778

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https://www.mdpi.com/2218-273X/12/12/1778

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