The Shank3Venus/Venus knock in mouse enables isoform-specific functional studies of Shank3a

The Shank3Venus/Venus knock in mouse enables isoform-specific functional studies of Shank3a

BackgroundShank3 is a scaffolding protein essential for the organization and function of the glutamatergic postsynapse. Monogenic mutations in SHANK3 gene are among the leading genetic causes of Autism Spectrum Disorders (ASD). The multiplicity of Shank3 isoforms seems to generate as much functional...

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Bibliographic Details
Main Authors: Nathalie Bouquier, Sophie Sakkaki, Fabrice Raynaud, Anne-Laure Hemonnot-Girard, Vincent Seube, Vincent Compan, Federica Bertaso, Julie Perroy, Enora Moutin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Neuroscience
Subjects:
Shank3
knock in
ASD model
isoform-specific tagging
Shank3Δ⁢C
Shank3a
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1081010/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.1081010/full

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