RNA Sequencing Data for FFPE Tumor Blocks Can Be Used for Robust Estimation of Tumor Mutation Burden in Individual Biosamples

RNA Sequencing Data for FFPE Tumor Blocks Can Be Used for Robust Estimation of Tumor Mutation Burden in Individual Biosamples

Tumor mutation burden (TMB) is a well-known efficacy predictor for checkpoint inhibitor immunotherapies. Currently, TMB assessment relies on DNA sequencing data. Gene expression profiling by RNA sequencing (RNAseq) is another type of analysis that can inform clinical decision-making and including TM...

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Bibliographic Details
Main Authors: Maxim Sorokin, Alexander Gorelyshev, Victor Efimov, Evgenia Zotova, Marianna Zolotovskaia, Elizaveta Rabushko, Denis Kuzmin, Alexander Seryakov, Dmitry Kamashev, Xinmin Li, Elena Poddubskaya, Maria Suntsova, Anton Buzdin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
TMB (tumor mutation burden)
RNAseq
FFPE (formalin-fixed paraffin-embedded)
machine learning
oncology
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.732644/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.732644/full

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