Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but they do not directly alleviate β cell stress nor prevent, let alone reverse, β...

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Bibliographic Details
Main Authors: Barak Blum, Adam N Roose, Ornella Barrandon, René Maehr, Anthony C Arvanites, Lance S Davidow, Jeffrey C Davis, Quinn P Peterson, Lee L Rubin, Douglas A Melton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-09-01
Series:eLife
Subjects:
beta cell
dedifferentiation
diabetes
Alk5 inhibitor II
Ucn3
Tgf-beta
Online Access:https://elifesciences.org/articles/02809

Internet

https://elifesciences.org/articles/02809

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