Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus

Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus

Enzymes in the thiol redox systems of microbial pathogens are promising targets for drug development. In this study we characterized the thioredoxin reductase (TrxR) selenoproteins from Brugia malayi and Onchocerca volvulus, filarial nematode parasites and causative agents of lymphatic filariasis an...

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Bibliographic Details
Main Authors: Francesca Fata, Radosveta Gencheva, Qing Cheng, Rachel Lullo, Matteo Ardini, Ilaria Silvestri, Federica Gabriele, Rodolfo Ippoliti, Christina A. Bulman, Judy A. Sakanari, David L. Williams, Elias S.J. Arnér, Francesco Angelucci
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Redox Biology
Subjects:
Thioredoxin reductase
Glutaredoxin
Selenocysteine
X-ray crystallography
Auranofin
Thioredoxin reductase inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000507

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http://www.sciencedirect.com/science/article/pii/S2213231722000507

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