Effective Synthesis of High-Integrity mRNA Using In Vitro Transcription

Effective Synthesis of High-Integrity mRNA Using In Vitro Transcription

mRNA vaccines are entering a period of rapid development. However, their synthesis is still plagued by challenges related to mRNA impurities and fragments (incomplete mRNA). Most impurities of mRNA products transcribed in vitro are mRNA fragments. Only full-length mRNA transcripts containing both a...

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Bibliographic Details
Main Authors: Wei He, Xinya Zhang, Yangxiaoyu Zou, Ji Li, Chong Wang, Yucai He, Qiuheng Jin, Jianren Ye
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Molecules
Subjects:
mRNA integrity
fragmented mRNA
transcription
T7 RNA polymerase
mutation
synthesis
Online Access:https://www.mdpi.com/1420-3049/29/11/2461

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https://www.mdpi.com/1420-3049/29/11/2461

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