Identification of Human UDP-Glucuronosyltransferase Involved in Gypensapogenin C Glucuronidation and Species Differences

Identification of Human UDP-Glucuronosyltransferase Involved in Gypensapogenin C Glucuronidation and Species Differences

Gypensapogenin C (GPC) is one of the important aglycones of <i>Gynostemma pentaphyllum</i> (GP), which is structurally glucuronidated and is highly likely to bind to UGT enzymes in vivo. Due to the important role of glucuronidation in the metabolism of GPC, the UDP-glucuronosyltransferas...

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Bibliographic Details
Main Authors: Juan Chen, Lin Qin, Xingdong Wu, Daopeng Tan, Yanliu Lu, Yimei Du, Di Wu, Yuqi He
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
gypensapogenin C
glucuronidation
human liver microsomes
UGT1A4
species differences
Online Access:https://www.mdpi.com/1422-0067/24/2/1454

Internet

https://www.mdpi.com/1422-0067/24/2/1454

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