Ligand-Based Pharmacophore Modeling, Molecular Docking, and Molecular Dynamic Studies of Dual Tyrosine Kinase Inhibitor of EGFR and VEGFR2

Ligand-Based Pharmacophore Modeling, Molecular Docking, and Molecular Dynamic Studies of Dual Tyrosine Kinase Inhibitor of EGFR and VEGFR2

Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2 (VEGFR2) play an important role in cancer growth. Both of them have close relationships. Expression of EGFR will induce an angiogenic factor (VEGF) release for binding with VEGFR2. However, the existence of VEG...

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Bibliographic Details
Main Authors: Frangky Sangande, Elin Julianti, Daryono Hadi Tjahjono
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
dual inhibitor
EGFR
VEGFR2
ligand-based pharmacophore
molecular docking
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/21/20/7779

Internet

https://www.mdpi.com/1422-0067/21/20/7779

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