Sulfated Hyaluronan Modulates the Functional Properties and Matrix Effectors Expression of Breast Cancer Cells with Different Estrogen Receptor Status

Sulfated Hyaluronan Modulates the Functional Properties and Matrix Effectors Expression of Breast Cancer Cells with Different Estrogen Receptor Status

Hyaluronan (HA) is an extracellular matrix glycosaminoglycan (GAG) that plays a pivotal role in breast cancer. While HA is the only GAG not normally substituted with sulfate groups, sulfated hyaluronan (sHA) has previously been used in studies with promising antitumor results. The aim of the present...

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Bibliographic Details
Main Authors: Christos Koutsakis, Anastasia-Gerasimoula Tavianatou, Dimitris Kokoretsis, Georgios Baroutas, Nikos K. Karamanos
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomolecules
Subjects:
sulfated hyaluronan
extracellular matrix
breast cancer
estrogen receptors
epithelial-to-mesenchymal transition
matrix metalloproteinases
Online Access:https://www.mdpi.com/2218-273X/11/12/1916

Internet

https://www.mdpi.com/2218-273X/11/12/1916

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