A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease

A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease

Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA). Turbulence in the levels of PAI-1 tilts the...

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Bibliographic Details
Main Authors: Gael B. Morrow, Claire S. Whyte, Nicola J. Mutch
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
PAI-1
fibrinolysis
metabolic syndrome
obese
diabetes
thrombosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.653655/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.653655/full

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