RNA Editing: A New Therapeutic Target in Amyotrophic Lateral Sclerosis and Other Neurological Diseases

RNA Editing: A New Therapeutic Target in Amyotrophic Lateral Sclerosis and Other Neurological Diseases

The conversion of adenosine to inosine in RNA editing (A-to-I RNA editing) is recognized as a critical post-transcriptional modification of RNA by adenosine deaminases acting on RNAs (ADARs). A-to-I RNA editing occurs predominantly in mammalian and human central nervous systems and can alter the fun...

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Bibliographic Details
Main Authors: Takashi Hosaka, Hiroshi Tsuji, Shin Kwak
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis (ALS)
excitotoxicity
RNA editing
α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors
adenosine deaminase acting on RNA 2 (ADAR2)
Online Access:https://www.mdpi.com/1422-0067/22/20/10958

Internet

https://www.mdpi.com/1422-0067/22/20/10958

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