Assessing the Effectiveness of Functional Genetic Screens for the Identification of Bioactive Metabolites

Assessing the Effectiveness of Functional Genetic Screens for the Identification of Bioactive Metabolites

A common limitation for the identification of novel activities from functional (meta) genomic screens is the low number of active clones detected relative to the number of clones screened. Here we demonstrate that constructing libraries with strains known to produce bioactives can greatly enhance th...

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Bibliographic Details
Main Authors: Staffan Kjelleberg, Torsten Thomas, Francesco Ballestriero, Malak Daim, Anahit Penesyan, Suhelen Egan
Format: Article
Language:English
Published: MDPI AG 2012-12-01
Series:Marine Drugs
Subjects:
antibacterial
antinematode
functional genomic screen
fosmid libraries
marine bacteria
marine bioactives
Caenorhabditis elegans
Online Access:http://www.mdpi.com/1660-3397/11/1/40

Internet

http://www.mdpi.com/1660-3397/11/1/40

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