Hypermetabolism in mice carrying a near-complete human chromosome 21

Hypermetabolism in mice carrying a near-complete human chromosome 21

The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism using a non-mosaic transchromosomic mouse model (TcM...

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Bibliographic Details
Main Authors: Dylan C Sarver, Cheng Xu, Susana Rodriguez, Susan Aja, Andrew E Jaffe, Feng J Gao, Michael Delannoy, Muthu Periasamy, Yasuhiro Kazuki, Mitsuo Oshimura, Roger H Reeves, G William Wong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
aneuploidy
trisomy
sarcolipin
SERCA pump
futile cycle
hypermetabolism
Online Access:https://elifesciences.org/articles/86023

Internet

https://elifesciences.org/articles/86023

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