The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system

The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system

Abstract Myelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein (Gαo) in mammalian nerve system, is required for normal motor function. Here, we...

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Bibliographic Details
Main Authors: Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu, Yun Gu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Acta Neuropathologica Communications
Subjects:
Gnao1
Schwann cells
Differentiation
(Re-)myelination
Cyclic AMP
Demyelinating diseases
Online Access:https://doi.org/10.1186/s40478-024-01720-3

Internet

https://doi.org/10.1186/s40478-024-01720-3

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