Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts

Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts

Cardiac contractility is regulated by several neural, hormonal, paracrine, and autocrine factors. Amongst these, signaling through β-adrenergic and serotonin receptors generates the second messenger cyclic AMP (cAMP), whereas activation of natriuretic peptide receptors and soluble guanylyl cyclases...

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Bibliographic Details
Main Authors: Gaia Calamera, Lise Román Moltzau, Finn Olav Levy, Kjetil Wessel Andressen
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
cardiomyocyte
inotropic response
lusitropic response
beta-adrenergic receptor
GC-A
GC-B
Online Access:https://www.mdpi.com/1422-0067/23/4/2145

Internet

https://www.mdpi.com/1422-0067/23/4/2145

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