Functional Brachyury binding sites establish a temporal read-out of gene expression in the Ciona notochord.

The appearance of the notochord represented a milestone in Deuterostome evolution. The notochord is necessary for the development of the chordate body plan and for the formation of the vertebral column and numerous organs. It is known that the transcription factor Brachyury is required for notochord...

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Main Authors: Lavanya Katikala, Hitoshi Aihara, Yale J Passamaneck, Stefan Gazdoiu, Diana S José-Edwards, Jamie E Kugler, Izumi Oda-Ishii, Janice H Imai, Yutaka Nibu, Anna Di Gregorio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-10-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3812116?pdf=render